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The Efficacy of Oral Melatonin in Improving Sleep in Cancer Patients with Insomnia: A Randomized Double-Blind

Madhuri S Kurdi1, Sindhu Priya Muthukalai1

  • 1Department of Anaesthesiology, Karnataka Institute of Medical Sciences, Hubli, Karnataka, India.

Indian Journal of Palliative Care
|August 26, 2016
PubMed
Abstract

Insights

Melatonin effectively improved sleep in cancer patients with insomnia. This study found that daily melatonin intake significantly enhanced sleep quality and induction, offering a promising treatment option.

Area of Science:

  • Oncology
  • Sleep Medicine
  • Pharmacology

Background:

  • Insomnia is a prevalent issue among cancer patients.
  • Melatonin, a natural hormone with sedative properties, has been underutilized for managing sleep disturbances in this population.
  • This study investigated the efficacy of melatonin for insomnia in cancer patients.

Purpose of the Study:

  • To evaluate the hypnotic effectiveness of oral melatonin in cancer patients experiencing insomnia.
  • To assess the impact of melatonin on sleep quality and induction in this specific patient group.

Main Methods:

  • A double-blind, placebo-controlled study was conducted with 50 cancer patients diagnosed with primary insomnia.
  • Participants received either 3 mg of melatonin or a placebo orally daily for 14 days.
  • Sleep quality was assessed using the Athens Insomnia Scale at multiple time points.

Main Results:

  • Melatonin treatment demonstrated a statistically significant improvement in insomnia symptoms (46.53%) compared to placebo (11.30%).
  • Improvements in sleep were observed early (1-7 days) and sustained throughout the study period (7-14 days).
  • The observed differences between melatonin and placebo were highly significant (P < 0.00001).

Conclusions:

  • Daily oral melatonin intake, administered 2 hours before bedtime, is effective in improving sleep induction and quality for cancer patients with insomnia.
  • Melatonin presents a viable therapeutic option for managing insomnia in oncology settings.
  • Further research may explore optimal dosing and long-term effects.
Keywords:
MalignanciesMelatoninOral administrationSleepSleep disorders

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