[Synthesis and antisecretory and anti-ulcer activity of new 4,6-diarylpyridazinones]

It has been possible to prepare from 4,6-diaryl pyridazinones a series of derivatives substituted in the 2-position and having urea moiety via the addition of free amines into methylisocyanate. Their gastric anti-secretory and anti-ulcer activities were evaluated. The compounds with an N-2 ethyl chain on the pyridazinone ring (IVa, IVd, IVg) were the most active derivatives.