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Dendrimer-based Uneven Nanopatterns to Locally Control Surface Adhesiveness: A Method to Direct Chondrogenic Differentiation

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Tailoring Patterns of Surface-Attached Multiresponsive Polymer Networks.

Benjamin Chollet¹, Loïc D'Eramo², Ekkachai Martwong¹

¹École Supérieure de Physique et de Chimie Industrielles (ESPCI Paris), PSL Research University, Sciences et Ingénierie de la Matière Molle, CNRS UMR 7615 and Sorbonne-Universités, UPMC Univ Paris 06, SIMM , 10 rue Vauquelin, Paris F-75231 Cedex 05, France.

ACS Applied Materials & Interfaces

|August 26, 2016

Summary

Researchers developed a new method for creating patterned hydrogels using thiol-ene click chemistry. This technique allows precise control over hydrogel chemistry and architecture for advanced material applications.

Keywords:

grafting hydrogel pattern photolithography polymer responsive thin film

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Area of Science:

Materials Science
Polymer Chemistry
Surface Chemistry

Background:

Fabricating surface-attached hydrogels with controlled chemistry is challenging.
Existing methods often lack precise control over polymer architecture and chemical functionality.
Need for versatile techniques to create functional hydrogel patterns on diverse substrates.

Purpose of the Study:

To develop a novel strategy for fabricating micropatterned surface-attached hydrogels.
To achieve well-controlled hydrogel chemistry and architecture.
To demonstrate the versatility of the approach on various substrates and with different responsive polymers.

Main Methods:

Utilized a "grafting onto" approach involving preformed, functionalized polymer chains.
Employed thiol-ene click chemistry for cross-linking and grafting under UV irradiation.
Applied photolithography (with and without photomasks using laser technology) for micropatterning.

Main Results:

Successfully fabricated micropatterned hydrogel thin films with excellent chemical control.
Demonstrated the fabrication on silicon wafers, glass, and gold substrates.
Created responsive hydrogels (poly(N-isopropylacrylamide) and poly(acrylic acid)) and stable hydrogel multilayers with tunable layer heights.

Conclusions:

The developed thiol-ene click chemistry approach offers facile and precise fabrication of hydrogel micropatterns.
The method provides high versatility in terms of substrate choice, polymer chemistry, and multilayer architecture.
This facile route for micrometer-resolute hydrogel patterns with tailored architecture and multiresponsive properties has significant potential impact.