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Related Experiment Videos

Hyperphagia induced by pylorectomy in sheep.

C H Malbert1, Y Ruckebusch

  • 1Department of Physiology, National Veterinary School, Toulouse, France.

Physiology & Behavior
|March 1, 1989
PubMed
Summary

Removing the pyloric sphincter in sheep increases food intake by speeding up digestion. This suggests the pylorus regulates appetite by controlling how long digesta stays in the stomach.

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Area of Science:

  • Animal Physiology
  • Gastroenterology
  • Ruminant Nutrition

Background:

  • The pylorus, a sphincter in the stomach, may play a role in regulating food intake.
  • Understanding the pylorus's function is crucial for comprehending digestive processes and appetite control in ruminants.

Purpose of the Study:

  • To investigate the role of the pylorus in regulating abomasal emptying and voluntary food intake in hay-fed sheep.
  • To determine if the pylorus acts as a satiety signal by limiting abomasal emptying.

Main Methods:

  • Sheep underwent pylorectomy (removal) or pyloroplasty (surgical widening) of the pylorus.
  • Abomasal emptying rate and digesta mean residence time were measured.
  • Voluntary food intake was monitored before and after surgery.

Main Results:

  • Pylorectomy and pyloroplasty significantly increased abomasal outflow.
  • Mean residence time of digesta in the abomasum decreased after surgery.
  • Voluntary food intake increased by 48% following pylorectomy, persisting for weeks.

Conclusions:

  • The pylorus acts as a distal stomach sphincter that limits abomasal emptying rate.
  • Removal or widening of the pylorus leads to hyperphagia (increased food intake).
  • The pylorus plays a key role in regulating voluntary food intake by modulating digesta residence time in the abomasum.

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