Related Experiment Video
Updated: Mar 15, 2026

07:45
Modeling Dysplastic and Functional Lung Alveolar Repair after Influenza Infection
Published on: September 19, 2025
586
Understanding Lung Development, Injury, and Repair
Chhavi Chauhan1, Kevin A Roth2
1American Society for Investigative Pathology, Bethesda, Maryland (Scientific Editor).
The American Journal of Pathology
|August 26, 2016
Summary
This editorial introduces a special issue on lung development and injury. It offers key insights into pulmonary diseases, lung repair, and overall lung health.
Area of Science:
- Pulmonology and Developmental Biology
Background:
- This editorial introduces a special theme issue focusing on lung ontogeny and injury.
- The issue consolidates critical insights into the complex processes of lung development, injury, and repair.
Discussion:
- It highlights advancements in understanding the mechanisms underlying various pulmonary diseases.
- The collection emphasizes the interconnectedness of developmental pathways and disease pathogenesis.
Key Insights:
- Provides a comprehensive overview of current knowledge in lung biology and pathology.
- Features research on the cellular and molecular basis of lung development and response to injury.
Outlook:
- Sets the stage for future research directions in pediatric and adult lung disease.
- Aims to foster a deeper understanding of lung health and disease management.
Related Concept Videos
Overview of Regeneration and Repair
5.7K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Regeneration
All animals have varying degrees of...
5.7K
Tissue Injury: Inflammation and Repair
5.7K
5.7K
Liver Regeneration
4.7K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.7K
Phases of Wound Repair
9.3K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
9.3K
Fractures: Bone Repair
6.4K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
6.4K
Neurogenesis and Regeneration of Nervous Tissue
2.0K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
2.0K

