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Updated: Mar 15, 2026
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Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
Published on: August 6, 2021
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Central Retinal Vein Occlusion Associated with Ulcerative Colitis.
Yuri Seo1, Min Kim, Jin Hyoung Kim
1*MD Departments of Ophthalmology (YS, JHK, SCL) and Internal Medicine (JJP), Gangnam Severance Hospital, Yonsei University College of Medicine, Gangnam-gu, Seoul, Republic of Korea.
Summary
Central retinal vein occlusion (CRVO) associated with ulcerative colitis can be effectively treated with intravitreal dexamethasone injections. This treatment resolved CRVO symptoms, even without macular edema, offering a new therapeutic option.
Area of Science:
- Ophthalmology
- Gastroenterology
- Pharmacology
Background:
- Ulcerative colitis (UC) is an inflammatory bowel disease.
- Central retinal vein occlusion (CRVO) is a rare but serious ocular complication of UC.
- This case highlights the association between UC and non-ischemic CRVO.
Observation:
- A 40-year-old male with UC presented with sudden visual disturbances.
- Fundus examination revealed retinal hemorrhages, cotton-wool spots, and optic disc swelling.
- Initial treatment with systemic corticosteroids was insufficient.
Findings:
- The patient was diagnosed with non-ischemic CRVO secondary to UC.
- Intravitreal dexamethasone injection led to the resolution of CRVO signs.
- Ocular coherence tomography showed inner retinal thinning post-treatment.
Implications:
- Intravitreal dexamethasone is a potential treatment for CRVO in UC patients, even without macular edema.
- This case expands treatment options for ocular manifestations of inflammatory bowel disease.
- Early intervention with targeted therapy can preserve vision in CRVO patients.
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