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Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
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[Deep brain stimulation in Parkinson's disease. Preliminary outcomes]
Ramiro Antonio Pérez-de la Torre1, Alejandra Calderón-Vallejo, Hugo Morales-Briceño
1Servicio de Neurocirugía, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México. neuropraxis@icloud.com.
Revista Medica Del Instituto Mexicano Del Seguro Social
|August 26, 2016
Summary
Deep brain stimulation (DBS) offers good to excellent outcomes for Parkinson's disease patients. This study shows minimal complications and improved Unified Parkinson Disease Rating Scale scores at mid and long-term follow-up.
Area of Science:
- Neurosurgery
- Neurology
- Medical Devices
Background:
- Parkinson's disease (PD) is a neurodegenerative disorder.
- Deep brain stimulation (DBS) is a therapeutic option for select PD patients.
- This study evaluates mid-term and long-term outcomes of DBS in 60 patients.
Purpose of the Study:
- To assess the efficacy and safety of DBS in Parkinson's disease patients.
- To report post-surgical outcomes at various time points.
- To evaluate complication rates and management.
Main Methods:
- Conventional stereotactic surgery using FrameLink software.
- Includes presurgical evaluation, imaging, planning, microrecording, macrostimulation, and electrode/generator placement.
- Unified Parkinson Disease Rating Scale (UPDRS) used for assessment pre-surgery and at 3, 12, and 36 months post-surgery.
Main Results:
- 60 patients (41 male, 19 female, average age 56.5 years) underwent DBS.
- Significant improvement in UPDRS scores observed: pre-op 79.57, 3-month 66.85, 12-month 65.29, 36-month 58.75 (p < 0.0001).
- Complications occurred in 9 patients (15%) and were managed conservatively.
Conclusions:
- DBS provided good to excellent post-surgical outcomes in the majority of Parkinson's disease patients.
- Complications were minimal and managed conservatively.
- DBS is a viable treatment option for selected Parkinson's disease patients.
