Synthesis of (125) I-lamivudine and (125) I-lamivudine-ursodeoxycholic acid codrug
M A Motaleb1, M Abo-Kul2, Samy M Ibrahim2
1Labelled Compounds Department, Hot Labs Centre, Atomic Energy Authority, Cairo, 13759, Egypt. mamotaleb10@yahoo.com.
Abstract:
The preparation of (125) I-lamivudine ((125) I-3TC) and (125) I-lamivudine-ursodeoxycholic acid codrug ((125) I-3TC-UDCA), suitable for comparative biodistribution studies, is described. The synthesis of the unlabeled precursor 3TC-UDCA proceeds in an 11.6% yield, and the radiolabelling yields for (125) I-3TC and (125) I-3TC-UDCA were 89 and 92%, respectively. The final products are radiochemically pure (greater than 98%).
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