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Updated: Mar 15, 2026

Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients
Published on: June 11, 2011
Increased homocysteine plasma level is associated with shortened prothrombin time in HIV-infected patients
Bernardino Roca1, Manuel Roca2, Guillermo Girones1
1a Medicine Department , Hospital General , Castellon , Spain.
Objective:
To find factors associated with increased homocysteine plasma level in HIV-infected patients.
Methods:
Cross-sectional study, carried out as a supplementary task to the standard care of HIV-infected patients. The possible association of increased homocysteine plasma level with blood analyses results was assessed with a multiple linear regression analysis, using the automatic linear modeling available in SPSS version 22.
Results:
A total of 145 patients were included. Creatinine was higher than normal in 7 patients (5%), prothrombin time was shortened in 36 patients (25%), and a monoclonal gammopathy was detected in 2 patients (1%). In the regression analysis, an association was found between high homocysteine plasma level and the following variables: low prothrombin time (β coefficient -0.286, confidence interval -1.1854 to -0.754, p < 0.001), high creatinine (coefficient 9.926, confidence interval 6.351-15.246, p < 0.001), low folic acid (coefficient -0.331, confidence interval -0-483 to -0.187, p < 0.001), and low vitamin B12 (coefficient -0.007, confidence interval -0.01 to -0.001, p = 0.005).
Conclusion:
An association was found between increased homocysteine plasma level and shortened prothrombin time.
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