Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

8.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.6K
Cancer Prevention02:59

Cancer Prevention

3.0K
3.0K
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

1.5K
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
1.5K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

6.1K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
6.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

5.0K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Precision oncology in adjuvant aspirin therapy for colorectal cancer: emerging genetic markers and persistent uncertainties.

EBioMedicine·2026
Same author

Aspirin or clopidogrel in chronic coronary syndromes: the saga continues.

European heart journal·2026
Same author

Weekly Journal Scan: Not all direct oral anticoagulants are created equal.

European heart journal·2026
Same author

Weekly Journal Scan: an OCEANIC wave redefines the role of factor XIa inhibition in stroke prevention.

European heart journal·2026
Same author

The crucial role of thromboxane A<sub>2</sub> in colorectal cancer development and metastasis: a key target for anticancer therapy.

Frontiers in pharmacology·2026
Same author

Weekly Journal Scan: Is left atrial appendage closure really non-inferior to anticoagulation in atrial fibrillation?

European heart journal·2026

Related Experiment Video

Updated: Mar 15, 2026

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NF&#954;B Activity and Breast Cancer Stem Cells
13:38

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Published on: January 18, 2017

12.7K

Aspirin and Cancer.

Paola Patrignani1, Carlo Patrono2

  • 1Department of Neuroscience, Imaging and Clinical Sciences and Center of Excellence on Aging, "G. D'Annunzio" University School of Medicine, Chieti, Italy.

Journal of the American College of Cardiology
|August 27, 2016
PubMed
Summary

Low-dose aspirin may help prevent cardiovascular disease (CVD) and colorectal cancer in certain adults. Current guidelines offer conflicting advice, but new evidence supports aspirin

Keywords:
chemopreventioncolorectal neoplasmscyclooxygenase-1nonsteroidal anti-inflammatory agentsplatelet activationprostaglandins

More Related Videos

Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module
10:39

Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module

Published on: June 18, 2015

13.9K
Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

9.2K

Related Experiment Videos

Last Updated: Mar 15, 2026

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NF&#954;B Activity and Breast Cancer Stem Cells
13:38

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Published on: January 18, 2017

12.7K
Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module
10:39

Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module

Published on: June 18, 2015

13.9K
Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

9.2K

Area of Science:

  • Preventive medicine
  • Oncology
  • Cardiology

Background:

  • Contradictory guidelines exist regarding aspirin's role in primary prevention.
  • Recent U.S. recommendations suggest low-dose aspirin for specific adults aged 50-59 to prevent cardiovascular disease (CVD) and colorectal cancer.
  • This shift is driven by growing evidence of aspirin's chemopreventive properties.

Purpose of the Study:

  • To review evidence supporting aspirin's chemopreventive effects.
  • To discuss potential mechanisms of aspirin's action.
  • To provide a framework for evaluating current guidelines amidst ongoing research.

Main Methods:

  • Literature review of studies on aspirin's chemopreventive effects.
  • Analysis of potential biological mechanisms.
  • Conceptual framework development for guideline assessment.

Main Results:

  • Evidence suggests a chemopreventive effect of low-dose aspirin, particularly against colorectal cancer.
  • The U.S. Preventive Services Task Force has issued specific recommendations for initiating aspirin use in select populations.
  • Ongoing studies are crucial for refining these recommendations.

Conclusions:

  • Aspirin shows promise as a chemopreventive agent for certain cancers and CVD.
  • Guidelines are evolving, reflecting new scientific evidence.
  • Further research is needed to optimize aspirin's role in primary prevention strategies.