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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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What is the Immune System?01:38

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Special Features of Adaptive Immunity01:20

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The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
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Antigens Involved in Adaptive Immunity01:26

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
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Immunological Memory01:23

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Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
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Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
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Related Experiment Video

Updated: Mar 15, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
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Immunometabolism and autoimmunity.

Jenny Freitag1, Luciana Berod1, Thomas Kamradt2

  • 1Institute of Infection Immunology, Twincore, Centre for Experimental and Clinical Infection Research GmbH, Hannover, Germany.

Immunology and Cell Biology
|August 27, 2016
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Summary

The study highlights how immune cell metabolism changes contribute to autoimmune diseases like arthritis, multiple sclerosis, and type 1 diabetes, suggesting new therapeutic targets in immunometabolism.

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Area of Science:

  • Immunology
  • Metabolism
  • Autoimmune Diseases

Background:

  • Autoimmune diseases are increasing globally, causing disability and high socio-economic costs.
  • Current treatments for autoimmune disorders are often ineffective, have side effects, and are not curative.
  • Innovative therapeutic strategies are needed to address the growing burden of autoimmune conditions.

Purpose of the Study:

  • To explore the role of immunometabolism in the pathogenesis of autoimmune diseases.
  • To discuss recent findings on metabolic alterations in specific autoimmune conditions.
  • To identify potential new therapeutic targets within the field of immunometabolism.

Main Methods:

  • Review of recent scientific literature on immunometabolism and autoimmune diseases.
  • Focus on pathophysiological aspects of metabolic changes.
  • Analysis of shared and distinct metabolic alterations across different autoimmune disorders.

Main Results:

  • Immune cell metabolism is increasingly recognized as a contributor to autoimmune disease development.
  • Specific metabolic pathways, metabolites (e.g., reactive oxygen species), and nutrient processing (e.g., amino acids, glucose) are altered in autoimmunity.
  • Metabolic dysregulation is a common feature across autoimmune arthritis, multiple sclerosis, and type 1 diabetes.

Conclusions:

  • The field of immunometabolism offers promising avenues for discovering novel therapeutic targets for autoimmune diseases.
  • Understanding metabolic changes in immune cells is crucial for developing more effective treatments.
  • Targeting metabolic pathways could provide innovative solutions for autoimmune conditions with unmet medical needs.