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Updated: Mar 15, 2026

Analysis of Oxidative Stress in Zebrafish Embryos
Published on: July 7, 2014
Oxidative stress equilibrium during obstetric event in normal pregnancy
Jose Manuel Salas-Pacheco1, Diana Lelidett Lourenco-Jaramillo2, Edna Madai Mendez-Hernandez1
1a Laboratorio de Biología Molecular del Instituto de Investigación Científica de la UJED , Avenida Universidad esq. con Volantín, Zona centro , Durango , Dgo , Mexico.
Objective:
The aim of this study was to determine malondialdehyde (MDA) concentration as an oxidative stress marker and total antioxidant capacity (TAC) in pregnancy before and after perinatal event.
Methods:
This study was performed on 200 healthy full-term pregnant women admitted to pregnancy resolution in Maternal-Child Hospital of Durango, Mexico. Oxidative stress and TAC were assessed through detection of lipid peroxidation by quantitation of thiobarbituric acid-reactive substances (TBARS) and TAC through ferric reducing ability of the plasma (FRAP).
Results:
Our results showed increased levels of MDA after vaginal delivery (VD). TAC was also increased after obstetric event, but it did not differ between VD and caesarean section.
Conclusions:
We demonstrated that MDA concentrations are increased two hours after obstetric event, and this increase correlates with VD. The TAC was increased as a compensatory mechanism during obstetric event. Another important finding is that women receiving analgesia administration in VD, as well as dexamethasone administration in caesarean section, experienced a protector effect that decreased MDA levels.
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