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Updated: Mar 15, 2026

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
Published on: December 3, 2016
[Bizarre parosteal osteochondromatous proliferation of the metatarsal bone]
C Hartog1, V Centmaier-Molnar1, R Patzwahl2
1Klinik für Orthopädie und Traumatologie, Kantonsspital Winterthur, Brauerstrasse 15, 8401, Winterthur, Schweiz.
Abstract:
A bizarre parosteal osteochondromatous proliferation (BPOP), also known as a Nora lesion, is a rare benign bone formation. It emanates mainly from the intact cortex of the metaphysis of short tubular bones (hands or feet). Conventional radiographs should be complemented using cross-sectional imaging modalities (CT/MRI). In the absence of symptoms a non-operative regime with radiological and clinical controls is possible. If symptomatic, excision biopsy is the treatment of choice, though a high recurrence rate has been reported. Histopathological examination confirms the diagnosis and typically shows an endochondral ossification zone and an unusually mineralized cartilaginous matrix referred to as "blue bone".
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