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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Related Experiment Video

Updated: Mar 15, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
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[Abnormality in bone metabolism after burn].

X Gong1, W G Xie

  • 1Institute of Burns, Wuhan Hospital NO.3&Tongren Hospital of Wuhan University, Wuhan 430060, China.

Zhonghua Shao Shang Za Zhi = Zhonghua Shaoshang Zazhi = Chinese Journal of Burns
|August 27, 2016
PubMed
Summary

Severe burns disrupt bone metabolism, leading to bone loss and reduced bone mineral density. These long-term effects, including growth issues in children, stem from stress responses and inflammation.

Area of Science:

  • Bone Metabolism
  • Burn Injury
  • Pediatric Growth

Background:

  • Burns significantly impact bone health, causing sustained metabolic abnormalities.
  • Decreased bone mineral density and impaired bone remodeling are common sequelae.
  • Growth retardation can occur in pediatric burn survivors.

Purpose of the Study:

  • To review the pathogenesis of bone metabolic abnormality post-burn.
  • To examine the relationship between burn severity and bone health.
  • To discuss current and future treatment strategies.

Main Methods:

  • Literature review of studies on burn injury and bone metabolism.
  • Analysis of factors contributing to bone metabolic changes.
  • Examination of clinical data relating burn characteristics to bone density.

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Main Results:

  • Burns trigger abnormal osteoblast and osteoclast activity, leading to bone mass loss.
  • Mechanisms include elevated glucocorticoids, inflammatory cytokines, vitamin D deficiency, and immobility.
  • Bone density reduction persists long-term, impacting growth.

Conclusions:

  • Burn-induced bone metabolic abnormality is a complex, multifactorial condition.
  • Understanding pathogenesis is crucial for effective treatment.
  • Further research is needed to optimize therapeutic interventions and address long-term bone health.