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Reviewing the epigenetics of schizophrenia
John Cromby1, Emma Chung2, Dimitris Papadopoulos1
1a ULSM.
Journal of Mental Health (Abingdon, England)
|August 27, 2016
Summary
Epigenetic research for schizophrenia shows promise but isn't revolutionary yet. Future studies should integrate social and biological factors, moving beyond solely molecular explanations and animal models.
Area of Science:
- Psychiatry
- Genetics
- Mental Health Research
Background:
- Epigenetic research in mental health has rapidly expanded.
- Schizophrenia is a key focus for evaluating epigenetic advancements.
- The field holds potential for novel interdisciplinary mental illness models.
Purpose of the Study:
- To review the relationship between epigenetics and schizophrenia.
- To identify key assumptions and issues in current epigenetic research for schizophrenia.
- To assess the progress and potential of epigenetics in understanding mental health.
Main Methods:
- Systematic literature search for papers on epigenetics and schizophrenia.
- Conceptually-driven narrative review.
- Analysis of empirical study issues and guiding assumptions.
Main Results:
- The revolutionary potential of epigenetics in schizophrenia is not yet realized.
- Hypotheses often focus narrowly on biological questions, reducing environmental influences to molecular outcomes.
- Over-reliance on animal studies limits consideration of relevant human environmental factors.
Conclusions:
- Epigenetic research in schizophrenia requires a more interdisciplinary approach.
- Hypotheses should incorporate social and biological influences.
- Reliance on traditional psychiatric diagnoses may need reconsideration.
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