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Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
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[Behcet's disease and infection].

M H Pei1, M F Zhang

  • 1Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

[Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology
|August 27, 2016
PubMed
Summary
This summary is machine-generated.

Behcet

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Area of Science:

  • Immunology
  • Ophthalmology
  • Microbiology

Background:

  • Behcet's disease (BD) is a systemic vasculitis with unknown cause.
  • Ocular manifestations, particularly uveitis, are common and difficult to treat in BD patients.
  • Genetic factors like HLA-B51 and environmental factors, including infections, are implicated in BD pathogenesis.

Purpose of the Study:

  • To review current research on the role of microbial infections in the pathogenesis of Behcet's disease.
  • To discuss the association between infections and immune disorders, specifically BD.
  • To provide recommendations for future research directions in BD and infection.

Main Methods:

  • Literature review of studies investigating microbial involvement in Behcet's disease.
  • Analysis of evidence linking various microbes to BD pathogenesis.
  • Synthesis of current understanding of infection's role in BD.

Main Results:

  • Accumulating evidence suggests microbial infections play a role in BD pathogenesis.
  • Several microbes, including Streptococcus sanguis, Staphylococcus aureus, intestinal flora, and herpes simplex virus, have been associated with BD.
  • Advances in bio-detecting technologies facilitate the identification of these associations.

Conclusions:

  • Infections are increasingly recognized as significant factors in the development of Behcet's disease.
  • Further research is needed to elucidate the precise mechanisms by which microbes contribute to BD.
  • Understanding the interplay between infection and immunity is crucial for future BD therapeutic strategies.