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Related Experiment Video

Updated: Mar 15, 2026

Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System
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An in vitro vascular chip using 3D printing-enabled hydrogel casting.

Liang Yang1, Shivkumar Vishnempet Shridhar, Melissa Gerwitz

  • 1Department of Biomedical and Chemical Engineering, Syracuse University, 900 S Crouse Ave, Syracuse NY 13210, USA.

Biofabrication
|August 27, 2016
PubMed
Summary
This summary is machine-generated.

Researchers engineered a 3D microfluidic vascular channel using 3D printing and hydrogel casting. This new method creates user-defined, functional blood vessel models for tissue engineering applications.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Microfluidics

Background:

  • Replicating complex vascular networks remains a significant challenge in tissue engineering.
  • Existing methods struggle to precisely control the geometry and function of engineered blood vessels.

Purpose of the Study:

  • To develop a user-defined 3D microfluidic vascular channel using 3D printing-enabled hydrogel casting.
  • To create a cytocompatible and rapid approach for engineering vascular chips.

Main Methods:

  • Fabrication of a hollow L-shaped channel via template casting using gelatin methacrylate (GelMA) hydrogel and UV photocrosslinking.
  • Encapsulation of murine 10T1/2 cells within the hydrogel.
  • Culturing of human umbilical vein endothelial cells (HUVECs) within the channel and visualization via immunostaining.
  • Assessment of endothelial monolayer barrier function using diffusion/permeability studies.

Main Results:

  • Successful engineering of a user-defined 3D microfluidic vascular channel.
  • Demonstration of HUVEC monolayer formation and barrier function within the engineered channel.
  • Validation of a facile, cytocompatible, and rapid method for vascular chip fabrication.

Conclusions:

  • The developed 3D printing-enabled hydrogel casting technique offers a promising solution for engineering vascular channels.
  • This approach facilitates the creation of multicellular vascular chips for advanced vascular model systems.
  • The method holds potential for applications in regenerative medicine and disease modeling.