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PPAR Ligands Function as Suppressors That Target Biological Actions of HMGB1

Shibo Ying1, Xiang Xiao2, Tianhui Chen1

  • 1Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.

PPAR Research
|August 27, 2016
PubMed

Insights

Peroxisome proliferator-activated receptors (PPARs) ligands suppress high mobility group box 1 (HMGB1) actions, offering potential for treating inflammatory disorders and cancers. This review explores PPAR ligands as therapeutic targets for HMGB1-related diseases.

Area of Science:

  • Molecular biology
  • Immunology
  • Oncology

Background:

  • High mobility group box 1 (HMGB1) is implicated in inflammatory disorders and cancers.
  • Ligand-activated peroxisome proliferator-activated receptors (PPARs) are closely associated with HMGB1.
  • PPAR ligands exhibit anti-inflammatory and anticancer properties.

Purpose of the Study:

  • To review evidence on PPAR ligands suppressing HMGB1 biological actions.
  • To elucidate mechanisms of PPAR involvement in inflammation.
  • To discuss the therapeutic potential of PPAR ligands targeting HMGB1 for cancer and inflammation.

Main Methods:

  • Literature review of experimental evidence.
  • Analysis of studies in cell lines and animal models.
  • Exploration of molecular and signaling pathways.

Main Results:

  • PPAR ligands inhibit HMGB1 intracellular expression.
  • PPAR ligands interfere with HMGB1 receptor signaling.
  • PPAR ligands reduce HMGB1 extracellular secretion.

Conclusions:

  • PPAR ligands demonstrate suppressive effects on HMGB1.
  • PPARs play a role in inflammatory disorders via HMGB1 modulation.
  • Targeting HMGB1 with PPAR ligands holds promise for cancer prevention and treatment.

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