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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors

Klemens Hoegenauer1, Nicolas Soldermann1, Frédéric Stauffer1

  • 1Global Discovery Chemistry, Center for Proteomic Chemistry, Metabolism and Pharmacokinetics, Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research , Novartis Campus, CH-4002 Basel, Switzerland.

ACS Medicinal Chemistry Letters
|August 27, 2016
PubMed

Keywords:
B cell inhibitionPI3Kδ inhibitorPK/PD studiesPhosphoinositide-3-kinase delta inhibitorlead optimizationstructure−activity relationship

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