Influence of age on the pharmacokinetics of ciprofloxacin

Data from 4 previously published reports on kinetics after oral ciprofloxacin administration are reviewed. Preliminary results from a study with oral and intravenous administration in elderly and young, healthy males are presented. The total clearance of ciprofloxacin is maintained in the elderly, while the renal clearance is reduced as a consequence of the age-related, physiological reduction of kidney functions. After oral administration there is, furthermore, an increased AUC and Cmax, which are explained by a higher bioavailability of an oral dose in the elderly (72.4%) as compared to young volunteers (58.4%).