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Related Experiment Videos

Does ciprofloxacin affect the inner ear? A preliminary report.

D Bagger-Sjöbäck1, M L Spångberg

  • 1Department of Otolaryngology, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden.

Scandinavian Journal of Infectious Diseases. Supplementum
|January 1, 1989
PubMed
Summary

Ciprofloxacin, a fluoroquinolone antibiotic, showed no significant ototoxic effects on guinea pig inner ear sensory epithelia, even at high doses. Mild hair cell changes were observed but did not indicate a toxic pattern.

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Area of Science:

  • Ototoxicity research
  • Pharmacology
  • Inner ear physiology

Background:

  • Ciprofloxacin is a widely used fluoroquinolone antibiotic.
  • Potential ototoxicity of fluoroquinolones requires investigation.
  • Inner ear sensory epithelia are crucial for hearing and balance.

Purpose of the Study:

  • To evaluate the potential ototoxic effects of ciprofloxacin on the inner ear.
  • To examine ultrastructural changes in vestibular and cochlear epithelia following ciprofloxacin administration.

Main Methods:

  • Adult guinea pigs were administered ciprofloxacin intraperitoneally at doses of 25, 50, 100, and 150 mg/kg/day.
  • Ultrastructural analysis of inner ear sensory epithelia (vestibular and cochlear) was performed post-sacrifice.
  • Animals were monitored for weight loss and appetite changes.

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Main Results:

  • High-dose ciprofloxacin administration led to appetite loss and rapid weight reduction in guinea pigs.
  • Overall structure of vestibular and cochlear sensory epithelia remained normal.
  • Mild, discrete changes in the sensory hairs of outer hair cells in the cochlea were observed at high doses, not consistent with known ototoxic damage patterns.

Conclusions:

  • Ciprofloxacin did not induce significant ototoxic damage to the inner ear sensory epithelia in guinea pigs.
  • Observed mild hair cell changes were not indicative of a toxic effect.
  • Current data suggest ciprofloxacin is not overtly ototoxic at the tested dosages.