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The effect of diclofenac sodium on renal function
A C Kinn1, J Elbarouni, P Seideman
1Department of Urology, Karolinska Hospital, Stockholm, Sweden.
Scandinavian Journal of Urology and Nephrology
|January 1, 1989
Summary
Diclofenac sodium significantly reduces urinary output and kidney function initially, but these effects are temporary. The drug
Area of Science:
- Nephrology
- Pharmacology
Background:
- Diclofenac sodium is a widely used nonsteroidal anti-inflammatory drug (NSAID).
- NSAIDs can affect renal function, but the specific impact of diclofenac sodium on kidney parameters requires detailed investigation.
Purpose of the Study:
- To investigate the acute effects of diclofenac sodium on renal function in patients with normal kidney function.
- To understand the mechanisms behind diclofenac's analgesic effect in conditions like ureteral colic.
Main Methods:
- A study involving eight patients with normal renal function.
- Monitoring of urinary output, renal plasma flow, glomerular filtration rate, and free water clearance over 4.5 hours post-injection.
Main Results:
- A rapid and significant decrease in urinary output (up to 80%) and initial reduction in renal plasma flow and glomerular filtration rate (35%).
- A dominant and persistent reduction in free water clearance, indicating increased tubular water reabsorption.
- Renal function parameters began to recover after 2 hours.
Conclusions:
- Diclofenac sodium causes transient but significant alterations in kidney function.
- Increased tubular water reabsorption may contribute to the reduced intrapelvic pressure and analgesic efficacy of diclofenac in ureteral colic.