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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
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Adaptive immunity programmes in breast cancer.

Frederick S Varn1, David W Mullins2,3,4, Hugo Arias-Pulido3

  • 1Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.

Immunology
|August 27, 2016
PubMed
Summary
This summary is machine-generated.

The adaptive immune system

Keywords:
T cellsadaptive immunitybreast cancerimmunotherapyneoantigens

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Area of Science:

  • Immunology
  • Oncology
  • Breast Cancer Research

Background:

  • The immune system's role in cancer development and prognosis is a key research area.
  • Adaptive immunity offers potential for tumor eradication but varies by tissue.
  • Understanding breast cancer's specific immune landscape is crucial.

Purpose of the Study:

  • To review adaptive immune responses in breast cancer.
  • To summarize key findings on breast tumor biology and immunity.
  • To discuss potential immunotherapeutic strategies for breast cancer.

Main Methods:

  • Literature review of adaptive immunity in breast cancer.
  • Analysis of cellular infiltration and immune cell functions.
  • Examination of hormone receptor and growth factor influence on immune response.

Main Results:

  • Adaptive immune programs in breast cancer have diverse roles, with some promoting eradication and others immunosuppression.
  • Tumor-specific immune responses are influenced by heterogeneous tumor biology.
  • Evidence suggests immunotherapy holds promise for breast cancer treatment.

Conclusions:

  • Adaptive immunity plays a complex, context-dependent role in breast cancer.
  • Targeting specific immune pathways may improve treatment efficacy.
  • Further research into breast cancer immunobiology is warranted to guide clinical immunotherapy.