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Related Concept Videos

Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

94
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
94
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

71
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
71
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

941
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
941
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

155
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
155
Modified-Release Drug Delivery Systems: Bioavailability01:30

Modified-Release Drug Delivery Systems: Bioavailability

75
Modified-release (MR) dosage forms are designed to extend drug release over time, thereby maintaining stable plasma concentrations and reducing dosing frequency. However, their bioavailability is typically below 100% due to incomplete drug release and presystemic metabolism, and limitations in drug permeability across the gastrointestinal epithelium, all of which can restrict the fraction of the drug reaching systemic circulation. Consequently, studying the in vivo bioavailability of MR...
75
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

173
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Quercetin topical application, from conventional dosage forms to nanodosage forms.

T Hatahet1, M Morille1, A Hommoss2

  • 1Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-ENSCM-UM, Equipe Matériaux Avancés Pour La Catalyse Et La Santé, 8 Rue de L'Ecole Normale, 34296 Montpellier Cedex 5, France.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|August 28, 2016
PubMed
Summary

Quercetin, a potent antioxidant flavonoid, shows promise for skin health by combating oxidation and inflammation. Formulation strategies are key to enhancing its topical delivery for wound healing and anti-aging benefits.

Keywords:
Antiinflammatory activityAntioxidant activityFranz cellsIn vitro skin penetrationIn vivo skin penetrationQuercetinSkin antiagingWound healing

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Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
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Area of Science:

  • Dermatology and Pharmaceutical Sciences
  • Investigating the role of natural compounds in skin health.
  • Exploring advanced formulation techniques for topical delivery.

Background:

  • The skin's defense mechanisms are challenged by environmental oxidants and inflammogens.
  • Exogenous antioxidants can bolster the skin's natural defenses against oxidative stress and inflammation.
  • Quercetin, a flavonoid, possesses significant antioxidant and anti-inflammatory properties, making it a potential candidate for skin applications.

Purpose of the Study:

  • To review the antioxidant and anti-inflammatory effects of quercetin on skin.
  • To discuss quercetin's role in wound healing and skin aging.
  • To present formulation strategies for enhancing quercetin's dermal penetration.

Main Methods:

  • Comprehensive literature review of research on quercetin for topical application over the past 25 years.
  • Analysis of studies on quercetin's biological effects in cellular and animal models.
  • Evaluation of various formulation approaches, including conventional emulsions and nanoformulations.

Main Results:

  • Quercetin demonstrates protective effects against UV irradiation and supports skin regeneration in wound healing.
  • Poor solubility limits quercetin's skin penetration, necessitating advanced formulation development.
  • Various topical formulations have been developed to improve quercetin's dermal delivery and efficacy.

Conclusions:

  • Quercetin holds significant potential for topical applications in dermatology due to its antioxidant and anti-inflammatory activities.
  • Overcoming quercetin's poor solubility through innovative formulations is crucial for maximizing its therapeutic benefits for skin.
  • Further research and development in quercetin-based topical formulations can advance treatments for skin aging and wound healing.