Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

636
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
636
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

312
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
312
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

419
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
419
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

351
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
351
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

682
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
682
Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

526
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
526

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Omalizumab for severe IgE-mediated food allergy and severe asthma after pediatric liver transplantation: a case report.

Frontiers in pediatrics·2026
Same author

European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) position paper on screening, diagnosis and investigation of paediatric metabolic dysfunction-associated steatotic liver disease.

Journal of pediatric gastroenterology and nutrition·2026
Same author

De novo variants in LDB1 are linked to distinct neurodevelopmental phenotypes determined by variant location and differing pathomechanisms.

American journal of human genetics·2026
Same author

Neuroradiological patterns and prognostic implications in type I Alexander disease.

Molecular genetics and metabolism·2026
Same author

Developmental trajectory of individuals with Pelizaeus-Merzbacher Disease (PMD).

Molecular genetics and metabolism·2026
Same author

Urinary miR-221-3p and miR-324-5p in combination with albuminuria as a promising model for non-invasive diagnosis of pediatric celiac disease.

Scientific reports·2026

Related Experiment Video

Updated: Mar 15, 2026

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats
11:01

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Published on: December 14, 2014

10.3K

Beverage consumption and paediatric NAFLD.

Antonella Mosca1, Claudia Della Corte2, Maria Rita Sartorelli2

  • 1Department of Paediatrics and Paediatric Neuropsychiatry, Centre of Paediatric Dietetics and Nutrition, Sapienza University, Rome, Italy. mosca_anto@libero.it.

Eating and Weight Disorders : EWD
|August 28, 2016
PubMed
Summary

Reducing sugary drinks like soft drinks and energy drinks can help prevent childhood obesity and non-alcoholic fatty liver disease (NAFLD). High sugar and calorie intake from these beverages significantly contribute to hepatic steatosis and non-alcoholic steatohepatitis (NASH).

Keywords:
AdolescentsAlcoholEnergy drinksFructoseNAFLDSoft drinks

More Related Videos

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

2.0K
Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
09:10

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents

Published on: November 1, 2019

11.7K

Related Experiment Videos

Last Updated: Mar 15, 2026

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats
11:01

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Published on: December 14, 2014

10.3K
Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

2.0K
Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
09:10

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents

Published on: November 1, 2019

11.7K

Area of Science:

  • Pediatric Gastroenterology
  • Hepatology
  • Nutrition Science

Background:

  • Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver condition in children and adolescents.
  • Rising global childhood obesity rates are a primary driver of NAFLD and non-alcoholic steatohepatitis (NASH).
  • Diets rich in carbohydrates and simple sugars are strongly linked to hepatic steatosis and NASH development.

Purpose of the Study:

  • To investigate the role of soft drinks and energy drinks in the pathogenesis and progression of NAFLD and NASH in young individuals.
  • To highlight the impact of high-calorie and high-sugar (particularly fructose) consumption from beverages on liver health.
  • To underscore the contribution of other beverage components, like xanthine, to metabolic disorders implicated in NAFLD/NASH.

Main Methods:

  • Review of existing scientific literature on NAFLD, NASH, childhood obesity, and beverage consumption.
  • Analysis of the association between simple sugar intake from soft drinks and energy drinks and metabolic co-morbidities.
  • Examination of the etiological role of specific beverage components in liver disease pathogenesis.

Main Results:

  • Increased consumption of simple sugars in beverages is positively correlated with overweight, obesity, and related conditions like type 2 diabetes and metabolic syndrome.
  • High calorie and sugar content, especially fructose, in soft drinks and energy drinks are major contributors to NAFLD and NASH.
  • Other ingredients in these drinks may also play a role in the metabolic dysregulation underlying NAFLD/NASH.

Conclusions:

  • A significant reduction in the consumption of energy drinks and soft drinks is a crucial intervention strategy.
  • This dietary modification is recommended for the effective prevention of obesity and NAFLD in the pediatric population.
  • Addressing sugar-sweetened beverage intake is vital for public health initiatives targeting childhood metabolic diseases.