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Related Experiment Video

Updated: Mar 15, 2026

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
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Intracranial Extraskeletal Mesenchymal Chondrosarcoma.

Nishanth Sadashiva1, Anil Sharma1, Dhaval Shukla1

  • 1Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India.

World Neurosurgery
|August 28, 2016
PubMed
Summary

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Intracranial extraskeletal mesenchymal chondrosarcomas (MCSs) are rare brain tumors. Complete surgical excision is crucial for managing these aggressive tumors, though outcomes vary significantly.

Area of Science:

  • Neuro-oncology
  • Surgical Pathology

Background:

  • Intracranial extraskeletal mesenchymal chondrosarcomas (MCSs) represent rare neoplasms, constituting less than 0.16% of all brain tumors.
  • Typically diagnosed in young adults (20-30 years), these tumors often arise in the frontoparietal region from the falx or dura mater.

Observation:

  • This report details three cases of intracranial MCSs in patients aged 7, 42, and 52 years, with diverse locations including anterior falx, mid-falcine, and left posterior lateral frontal dura.
  • One case presented with significant bone hyperostosis and a comatose state, highlighting varied clinical presentations.
  • Histopathological confirmation via immunohistochemistry was performed for all cases.

Findings:

  • Complete surgical excision was achieved for all three patients, yet their post-operative outcomes demonstrated considerable variability.
Keywords:
HemangiopericytomaMeningeal tumorMeningiomaMesenchymal chondrosarcomaMesenchymal tumor

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  • Intracranial MCSs are malignant tumors associated with a generally poor prognosis.

    • Implications:

    • The rarity of intracranial MCSs can lead to delayed diagnosis, as they are often overlooked in differential diagnoses and may be misidentified radiologically.
    • Radical surgical excision is emphasized as a critical management strategy.
    • The efficacy of adjuvant radiotherapy and chemotherapy remains a subject of ongoing debate and investigation.