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Updated: Mar 15, 2026

Investigating Intestinal Inflammation in DSS-induced Model of IBD
Published on: February 1, 2012
Soluble ST2 is a sensitive clinical marker of ulcerative colitis evolution
David Díaz-Jiménez1, Marjorie De la Fuente1,2, Karen Dubois-Camacho1
1Programa Disciplinario de Inmunología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, CL, 8380453, Chile.
Soluble ST2 (sST2) effectively predicts treatment response and clinical outcomes in ulcerative colitis (UC) patients. Measuring sST2 levels helps monitor inflammatory activity and patient prognosis, similar to fecal calprotectin.
Area of Science:
- Gastroenterology
- Immunology
- Biomarker Discovery
Background:
- The ST2/IL-33 pathway is implicated in ulcerative colitis (UC) pathogenesis.
- Soluble ST2 (sST2) levels correlate with UC disease severity.
Purpose of the Study:
- To evaluate soluble ST2 (sST2) as a predictive biomarker for treatment response in UC patients.
- To assess the utility of sST2 in predicting patient outcomes in UC.
Main Methods:
- Prospective study of 26 active UC patients, grouped by endoscopic score and therapy response.
- Collected serum, mucosal biopsies, and stool samples at various time points for sST2 and fecal calprotectin (FC) analysis.
- Correlated sST2 levels with clinical/endoscopic scores and FC using statistical analysis.
Main Results:
- sST2 levels significantly decreased in responders and remained high in non-responders over 6 months.
- sST2 levels correlated strongly with Mayo clinical/endoscopic subscores, mucosal ST2, and FC.
- Elevated sST2 was observed in non-responders, localized to the lamina propria's cellular infiltrate.
Conclusions:
- Consecutive sST2 measurements can track inflammatory activity changes in UC patients.
- sST2 is a valuable biomarker for predicting clinical outcomes in UC, comparable to FC.
- sST2 aids in assessing treatment response and prognosis for ulcerative colitis patients.
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