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Updated: Mar 15, 2026

Protocol for Plasmodium falciparum Infections in Mosquitoes and Infection Phenotype Determination
Published on: July 4, 2007
Source identification of autochthonous-introduced Plasmodium vivax Malaria, Spain
Laura Barrado1,2, Carmen Ezpeleta3,4, José Miguel Rubio5
1Clinical Microbiology Department, Hospital García Orcoyen, Santa Soria s/n, 31200, Estella, Navarra, Spain. ljbb550@msn.com.
Abstract:
In 2014, an autochthonous case of introduced malaria caused by Plasmodium vivax was identified in Spain. The strain that infected this patient was identical to that of a prior imported case from Pakistan. This is the first case where the source of infection could be identified since elimination in Spain.
Insights
A 2014 malaria case in Spain, caused by Plasmodium vivax, was traced to a previous imported case from Pakistan. This marked the first identified source of autochthonous malaria since Spain
Area of Science:
- Medical Entomology
- Infectious Diseases
- Parasitology
Background:
- Malaria, a disease caused by Plasmodium parasites, has been eliminated in Spain.
- Introduced malaria cases pose a public health concern, requiring source identification for control.
Observation:
- An autochthonous (locally acquired) case of Plasmodium vivax malaria was diagnosed in Spain in 2014.
- Genetic analysis revealed the infecting Plasmodium vivax strain was identical to a previously imported case from Pakistan.
Findings:
- The source of the autochthonous malaria infection was definitively identified.
- This represents the first instance of tracing an autochthonous malaria case to its origin since Spain's malaria elimination.
Implications:
- Highlights the ongoing risk of introduced malaria even in formerly endemic regions.
- Emphasizes the importance of robust surveillance and genetic tools for identifying malaria transmission sources.
- Informs strategies for preventing the re-establishment of malaria transmission in elimination settings.
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