Nephrogenic adenoma of the bladder: urographic spectrum

Nephrogenic adenoma is a rare, proliferative response of urothelium to urinary infection or injury of the bladder mucosa. Histologically, the lesion resembles proximal tubules of the nephron. While it can occur throughout the urinary tract, it usually appears in the bladder, with diverse radiographic manifestations. Of 6 patients with nephrogenic adenoma of the bladder, 3 presented with masses in the bladder and 2 with irregularities of the bladder mucosa on urography, while 1 showed no focal urographic abnormalities. There were no distinctive radiographic features of nephrogenic adenoma that would allow it to be differentiated from tumor or other inflammatory lesions. Although it is considered benign, bladder involvement may be extensive and eradication of the tumor may be difficult.