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Estimated burden of group a streptococcal pharyngitis among children in Beijing, China
Shuangsheng Wu1,2, Xiaomin Peng1,2, Zuyao Yang3
1Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, No. 16 Hepingli Middle Street, Dongcheng District, Beijing, 100013, China.
Insights
Group A Streptococcus (GAS) pharyngitis is common in Beijing children, with higher rates in older children. This study quantines the burden of GAS pharyngitis and associated outpatient visits in China.
Area of Science:
- Pediatric infectious diseases
- Epidemiology
- Microbiology
Background:
- Group A Streptococcus (GAS) pharyngitis burden is largely unknown in China.
- Limited data exists on GAS pharyngitis incidence and outpatient visits in developing countries.
Purpose of the Study:
- To determine the incidence of clinical pharyngitis and GAS culture-positive pharyngitis.
- To estimate outpatient visits for pharyngitis among children aged 0-14 years in Beijing, China.
Main Methods:
- A multiplier model was employed for estimations.
- Data incorporated clinical cases, GAS culture-positive rates, consultation rates, and surveillance data from Beijing.
- Key parameters included population coverage, sampling success, and test sensitivity.
Main Results:
- An average of 29,804.6 clinical pharyngitis cases per 100,000 person-years were observed in children aged 0-14.
- GAS culture-positive pharyngitis averaged 2,685.1 cases per 100,000 person-years.
- Children aged 5-14 years exhibited a higher burden of GAS pharyngitis compared to those aged 0-4 years.
Conclusions:
- Group A Streptococcus pharyngitis is highly prevalent in Chinese children.
- Further surveillance is recommended to monitor trends and evaluate control strategies.
Background:
Burden of Group A streptococcus (GAS) pharyngitis is scarce in developing countries, still unknown in China. The objective of this study was to determine the incidence of clinical cases of pharyngitis and GAS culture-positive pharyngitis, and their outpatient visits among children aged 0-14 years in Beijing, the capital of China.
Methods:
Multiplier model was used to estimate the numbers of pharyngitis cases, based on reported numbers of clinical cases and GAS culture-positive rates from GAS surveillances in Beijing, consultation rate, population coverage of GAS surveillances, sampling success rate, and test sensitivity of GAS culture from previous studies, surveys and surveillances.
Results:
An average of 29804.6 (95 % CI: 28333.2-31276.0) clinical cases of pharyngitis per 100,000 person-years occurred among children aged 0-14 years, resulting in correspondingly 19519.0 (95 % CI: 18516.7-20521.2) outpatient visits per 100,000 person-years from 2012 to 2014 in Beijing. On average, there were 2685.1 (95 % CI: 2039.6-3330.6) GAS culture-positive cases of pharyngitis and 1652.7 (95 % CI: 1256.5-2049.0) outpatient visits per 100,000 person-years during the same period. The estimated burden of GAS pharyngitis was significantly higher than that of scarlet fever. Children aged 5-14 years had a higher burden of GAS pharyngitis than those aged 0-4 years.
Conclusions:
The present data suggests that GAS pharyngitis is very common in children in China. Further studies and surveillances are needed to monitor trends and the effectiveness of control measures.
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