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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
Published on: February 9, 2011
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Paediatric Staphylococcus aureus bacteraemia: A single-centre retrospective cohort
Jessica C Roediger1, Alexander C Outhred2, Bruce Shadbolt3
1Department of General Medicine, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Journal of Paediatrics and Child Health
|August 28, 2016
Summary
Community-associated Staphylococcus aureus bacteraemia (SAB) and SAB linked to central venous access devices (CVADs) have increased in children. While the health burden is significant, mortality remains low.
Area of Science:
- Pediatric Infectious Diseases
- Clinical Epidemiology
- Microbiology
Background:
- Staphylococcus aureus bacteraemia (SAB) is a significant pediatric infection.
- Understanding trends in SAB is crucial for effective management.
- Previous data from our institution provides a baseline for comparison.
Purpose of the Study:
- To describe the clinical epidemiology of SAB in a tertiary/quaternary Australian children's hospital.
- To compare current SAB data with historical data from 1994-1998.
- To analyze trends in community-associated (CA-SAB) versus healthcare-associated (HCA-SAB) and methicillin-resistant (MRSA) versus methicillin-susceptible (MSSA) S. aureus.
Main Methods:
- Retrospective chart review of SAB cases from 2006-2011.
- Comparison of epidemiological data with a previous study period (1994-1998).
- Stratification of cases by association with healthcare, community acquisition, and MRSA/MSSA status.
Main Results:
- 174 pediatric SAB episodes identified; annual admission rate stable at 1.3/1000.
- Community-associated SAB (CA-SAB) comprised 49% of cases; MRSA was present in 18%.
- Increased proportions of community-associated MRSA (CA-MRSA) bacteraemia (22%) and SAB associated with central venous access devices (CVADs; 40%) were observed.
Conclusions:
- Over 18 years, CA-MRSA and CVAD-associated SAB have increased in pediatric patients.
- Two distinct phenotypes of pediatric SAB (HCA and CA) were identified.
- Infective endocarditis (IE) was infrequent, and overall mortality from pediatric SAB was low.
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