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Longitudinal T1 relaxation rate (R1) captures changes in short-term Mn exposure in welders.

Mechelle M Lewis1, Michael R Flynn2, Eun-Young Lee3

  • 1Department of Neurology, Pennsylvania State University College of Medicine-Milton S. Hershey Medical Center, Hershey, PA, USA; Department of Pharmacology, Pennsylvania State University College of Medicine-Milton S. Hershey Medical Center, Hershey, PA, USA.

Neurotoxicology
|August 29, 2016
PubMed
Summary

T1 relaxation rate (R1) values reflect short-term manganese (Mn) exposure dynamics in welders. R1 changes correlated with welding hours, unlike blood Mn levels or pallidal index, suggesting R1

Keywords:
LongitudinalMRIManganeseR1Welders

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Area of Science:

  • Neuroimaging
  • Occupational Health
  • Biomarkers

Background:

  • Manganese (Mn) exposure in welders is a concern.
  • Previous studies showed T1 relaxation rate (R1) captures chronic Mn exposure.
  • The utility of R1 for short-term Mn exposure dynamics remains unclear.

Purpose of the Study:

  • To investigate if R1 values reflect short-term Mn exposure dynamics in welders.
  • To compare R1 changes with traditional Mn biomarkers.

Main Methods:

  • Longitudinal study of 29 welders over 12 months.
  • Assessed short-term welding exposure via welding hours in the prior 90 days (HrsW90).
  • Measured blood Mn, pallidal index (PI), and R1 values in brain regions of interest (ROIs).
  • Used Spearman's correlations to associate changes in HrsW90 with changes in Mn biomarkers.

Main Results:

  • Changes in HrsW90 significantly correlated with changes in R1 values in the putamen, caudate, globus pallidus, amygdala, and hippocampus.
  • No significant association was found between changes in HrsW90 and changes in blood Mn levels or PI.
  • R1 values demonstrated sensitivity to short-term fluctuations in Mn exposure.

Conclusions:

  • R1 values effectively capture short-term changes in brain Mn accumulation related to welding.
  • R1 may serve as a valuable biomarker for dynamic Mn exposure assessment in occupational settings.
  • R1 offers advantages over traditional biomarkers for tracking recent Mn exposure.