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Updated: Mar 15, 2026

Growth-based Determination and Biochemical Confirmation of Genetic Requirements for Protein Degradation in Saccharomyces cerevisiae
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The Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Complex Manages a Key Checkpoint in B Cell Development

Yewei Ji1, Hana Kim2, Liu Yang1

  • 1Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.

Cell Reports
|August 30, 2016
PubMed
Summary

The Sel1L-Hrd1 endoplasmic reticulum-associated degradation (ERAD) complex is crucial for early B cell development. Its absence causes a developmental block by allowing persistent pre-B cell receptor signaling.

Keywords:
B cell developmentHrd1Sel1Lendoplasmic reticulum-associated degradationlarge pre-B cellspre-B cell receptor

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