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Published on: December 6, 2016
Outcomes Associated with Early Postoperative Noninvasive Ventilation in Bariatric Surgical Patients with Sleep Apnea
Mihaela S Stefan1,2,3, Nicholas S Hill4, Karthik Raghunathan5
1Center for Quality of Care Research, Baystate Medical Center, Springfield, MA.
Insights
Early noninvasive ventilation (NIV) in obstructive sleep apnea (OSA) patients after bariatric surgery did not improve outcomes like intubation or mortality. Further controlled trials are needed to confirm these findings for OSA patients.
Area of Science:
- Critical Care Medicine
- Sleep Medicine
- Bariatric Surgery Outcomes
Background:
- Obstructive sleep apnea (OSA) is common in patients undergoing bariatric surgery.
- Postoperative respiratory complications are a concern in this patient population.
- Noninvasive ventilation (NIV) is sometimes used to manage respiratory issues.
Purpose of the Study:
- To investigate the association between early initiation of noninvasive ventilation (NIV) and postoperative outcomes.
- To identify factors predicting early NIV use in patients with OSA undergoing bariatric surgery.
Main Methods:
- A large observational study included 5,266 patients with OSA from 161 US hospitals.
- Early postoperative NIV was defined as use on the day of or day after surgery.
- Propensity score matching was used to compare outcomes between NIV and no-NIV groups.
Main Results:
- Nearly 19% of patients received early NIV.
- Predictors for NIV included male sex, older age, COPD, gastric bypass, narcotics, and high OSA diagnosis rates.
- Early NIV initiation was not significantly associated with reduced invasive mechanical ventilation, cardiovascular complications, or mortality.
Conclusions:
- Early postoperative NIV in OSA patients undergoing bariatric surgery showed no significant benefit in reducing intubation or mortality.
- Further high-quality, randomized controlled trials are required to definitively answer the clinical question regarding NIV efficacy.
Study Objectives:
To examine the relationship of early initiation of noninvasive ventilation (NIV) with postoperative outcomes in patients with obstructive sleep apnea (OSA) undergoing bariatric surgery.
Methods:
We included 5,266 patients with OSA undergoing bariatric surgeries at 161 hospitals in the United States. We defined early postoperative NIV as NIV used on the day of or the day after surgery; this could include prophylactic NIV or NIV used for early signs of respiratory deterioration. We developed a hierarchical model to identify factors associated with early use of NIV. Then, in a propensity matched cohort, we assessed the association between NIV use and outcomes.
Results:
Overall, 996 patients (18.9%) were treated with early postoperative NIV. Predictors of NIV initiation were: male sex (odds ratio: 1.34, 95% confidence interval 1.14-1.59), older age, chronic obstructive pulmonary disease (COPD; odds ratio 1.39, confidence interval: 1.17-1.64), gastric bypass surgery, short-acting narcotics intravenous on the day of surgery and admission to a hospital with high rate of OSA diagnosis. In a propensity matched analysis, we found no significant association between early initiation of NIV and receipt of invasive mechanical ventilation (IMV) (early NIV 4.5% vs. no NIV 3.8% p = 0.46), cardiovascular complications or mortality. Results were consistent in several sensitivity analyses.
Conclusions:
In this large observational study of patients with OSA undergoing bariatric surgery, early postoperative NIV use was not associated with better outcomes including less intubation and mortality. Properly designed controlled trials will be necessary to provide more definitive answers to this important clinical question.
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