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Correlations of magnetic resonance, perfusion-weighed imaging parameters and microvessel density in meningioma
Ruihua Shi1, Tao Jiang, Lifang Si
1Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Purpose:
To investigate the correlations of magnetic resonance, perfusion-weighed imaging (PWI) parameters and microvessel density (MVD) in meningioma.
Methods:
48 patients with pathologically confirmed meningioma (grade I, 38 cases; grade II+III, 10 cases) completed preoperative routine magnetic resonance imaging (MRI) and PWI. The cerebral blood volume (CBV) map of solid tumor region and the mean of maximum relative cerebral blood volume (rCBV) were then calculated. Immunohistochemical staining was performed in all specimens to measure the MVD.
Results:
On the CBV map, benign meningiomas showed a high perfusion signal, while malignant meningiomas exhibited a slightly higher one. The rCBV of benign meningiomas was 9.61±4.76, which was significantly higher than 3.61±0.25 of malignant meningiomas (t=7.165, p=0.000). The MVD of benign meningioma strips was 21.16 ± 11.32, which was also significantly higher than 10.71 ± 5.53 strips of malignant meningiomas (t=2.325, p=0.026). The correlation analysis showed that the mean of maximum rCBV and MVD of meningiomas had significant positive correlations (r=0.718, p=0.000).
Conclusions:
The CBV map of benign meningiomas is different to that of malignant meningiomas, and the mean of maximum rCBV and MVD have significant positive correlations.
Insights
Magnetic resonance imaging (MRI) and perfusion-weighed imaging (PWI) reveal differences in cerebral blood volume (CBV) between benign and malignant meningiomas. Higher rCBV and microvessel density (MVD) correlate positively in these brain tumors.
Area of Science:
- Neuroimaging
- Oncology
- Pathology
Background:
- Meningiomas are primary brain tumors with varying grades.
- Accurate preoperative differentiation between benign and malignant meningiomas is crucial for treatment planning.
Purpose of the Study:
- To investigate the correlations between magnetic resonance imaging (MRI), perfusion-weighed imaging (PWI) parameters, and microvessel density (MVD) in meningioma.
- To differentiate benign from malignant meningiomas using imaging biomarkers.
Main Methods:
- 48 patients with pathologically confirmed meningioma underwent preoperative MRI and PWI.
- Cerebral blood volume (CBV) and mean of maximum relative cerebral blood volume (rCBV) were calculated.
- Microvessel density (MVD) was measured via immunohistochemical staining.
Main Results:
- Benign meningiomas showed higher perfusion signals on CBV maps compared to malignant ones.
- Benign meningiomas exhibited significantly higher rCBV (9.61±4.76) and MVD (21.16±11.32) than malignant meningiomas (rCBV: 3.61±0.25, MVD: 10.71±5.53).
- A significant positive correlation was found between mean maximum rCBV and MVD (r=0.718, p=0.000).
Conclusions:
- Cerebral blood volume (CBV) maps can distinguish between benign and malignant meningiomas.
- Mean maximum relative cerebral blood volume (rCBV) and microvessel density (MVD) are positively correlated in meningiomas.
- These imaging parameters may aid in the preoperative assessment of meningioma grade.
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