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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Related Experiment Video

Updated: Mar 15, 2026

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation
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Decrease of Airway Allergies After Lung Transplantation Is Associated With Reduced Basophils and Eosinophils.

M Niedzwiecki1, Y Yamada1, I Inci1

  • 1Division of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.

Transplantation Proceedings
|August 30, 2016
PubMed
Summary

Airway allergies often disappear after lung transplantation. This reduction correlates with decreased levels of basophils and eosinophils, suggesting their role in allergy development.

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Area of Science:

  • Immunology
  • Transplant Surgery
  • Allergy Research

Background:

  • Allergies involve immune hypersensitivity to antigens, similar to transplant rejection.
  • Lung transplant recipients face dual antigen exposure from blood and air.
  • The impact of lung transplantation on pre-existing airway allergies requires investigation.

Purpose of the Study:

  • To determine if airway allergies change following lung transplantation.
  • To analyze the association between allergy changes and specific immune cell counts post-transplant.

Main Methods:

  • Systematic review of lung transplant patients with airway allergies (1992-2014).
  • Analysis of lymphocyte, thrombocyte, and leukocyte (neutrophils, eosinophils, basophils) counts before and after lung transplantation.
  • Comparison of cell counts in patients with and without allergy resolution post-transplant.

Main Results:

  • 12.2% of 362 lung transplant patients had allergies pre-transplant.
  • Airway allergies resolved in 45.5% of these patients within one year post-transplant.
  • Significant decreases in basophils, eosinophils, and leukocytes (including neutrophils) were observed in patients whose allergies resolved (P < .0012 to P < .012).

Conclusions:

  • Nearly half of lung transplant recipients experienced resolution of airway allergies.
  • Decreased basophil and eosinophil counts accompanied allergy resolution, implicating them in allergic responses.
  • Further research into basophils and eosinophils as key mediators of airway allergies is warranted.