Related Experiment Video

Updated: Mar 15, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

1.3K

Thrombosis in Continuous Flow Left Ventricular Assist Devices: Our Clinical Experience With Medical and Surgical

U Köksel1, O Erbasan1, Ö Bayezid1

  • 1Department of Cardiovascular Surgery, Akdeniz University Hospital, Antalya, Turkey.

Transplantation Proceedings
|August 30, 2016
PubMed

Insights

Pump thrombosis in continuous-flow left ventricular assist devices (CF-LVADs) is linked to high blood pressure and poor anticoagulation. Thrombolytic therapy is an option but carries bleeding risks.

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Medical Device Technology

Background:

  • Continuous-flow left ventricular assist devices (CF-LVADs) are crucial alternatives to heart transplantation.
  • Pump thrombosis is a significant complication affecting CF-LVADs, including HeartMate II and HeartWare devices.
  • Understanding predisposition factors and treatment strategies for CF-LVAD thrombosis is vital.

Purpose of the Study:

  • To analyze predisposition factors for pump thrombosis in CF-LVAD patients.
  • To evaluate the center's approach to treating pump thrombosis.
  • To assess patient outcomes following treatment for pump thrombosis.

Main Methods:

  • Retrospective review of a CF-LVAD database (January 2011 - January 2015).
  • Comparison of patients with pump thrombosis (n=13) versus without (n=85).
  • Analysis of device type, predisposition factors, treatment, and outcomes.

Main Results:

  • Pump thrombosis occurred in 13 of 98 patients; no difference between HeartMate II and HeartWare devices.
  • High mean arterial blood pressure and noncompliance with anticoagulation were significant risk factors.
  • Thrombolytic therapy was used for most patients, with some requiring pump exchange; bleeding complications occurred.

Conclusions:

  • Optimizing blood pressure and anticoagulation adherence may reduce CF-LVAD pump thrombosis.
  • Thrombolytic therapy is a less invasive treatment option for pump thrombosis but has risks.
  • Careful patient selection and monitoring are essential when using thrombolytic therapy for CF-LVAD thrombosis.
Abstract

More Related Videos

Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device07:41

Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device

Published on: July 20, 2022

2.5K
Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock07:39

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Published on: August 16, 2021

4.2K

Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
453
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
634
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
1.6K
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
356
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
582
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
422