Related Experiment Video
Updated: Mar 15, 2026
09:33
Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
Published on: August 25, 2023
1.8K
PALME: PAtients Like My gEnome
Lichang Wang1, Yong Fang1, Dima Aref2
1College of Information Engineering, Northwest A&F University, Yangling, Shaanxi, China.
Summary
Patients Like My Genome (PALME) is a web service matching patients using genomic and health data. It aids researchers and individuals in exploring genetic connections to health conditions.
Area of Science:
- Genomics
- Bioinformatics
- Personalized Medicine
Background:
- Genomic data analysis is crucial for understanding disease.
- Matching patients by genetic profiles can reveal health correlations.
- Existing tools lack comprehensive integration of genomic and clinical data.
Purpose of the Study:
- To introduce Patients Like My Genome (PALME), a web service for matching patients based on genomic and healthcare profiles.
- To provide a tool for both biomedical researchers and individuals to explore genetic and health data.
- To facilitate the discovery of genotype-phenotype relationships.
Main Methods:
- Utilized the Personal Genome Project (PGP) dataset containing 4,360 patient profiles.
- Developed PALME to support two input types: dual query (variant + phenotype) and genome sequences.
- Implemented Hamming distance for calculating genomic similarity.
Main Results:
- PALME successfully matches patients based on genomic and phenotype data.
- The system displays matching patient profiles for dual queries.
- For genome sequence queries, PALME shows phenotype distributions of similar patients.
Conclusions:
- PALME is an interactive web service supporting healthcare profile matching.
- The tool enhances human genome studies for researchers.
- PALME empowers individuals to explore personal genetics and health.
More Related Videos
Related Concept Videos
02:02Genomics
41.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
41.5K
02:54Evolutionary Relationships through Genome Comparisons
7.2K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.2K
01:11Genome-wide Association Studies-GWAS
16.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
16.5K
01:29Modern Molecular Taxonomy
815
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
815
03:36Genome Annotation and Assembly
21.4K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
21.4K