Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Different protein diets in renal failure: a self-controlled study.

L Oldrizzi1, C Rugiu, G Maschio

  • 1Division of Nephrology, University Hospital, Verona, Italy.

American Journal of Nephrology
|January 1, 1989
PubMed
Summary

Dietary protein and phosphate intake significantly impacts chronic renal failure progression. Limiting intake to 0.6 g/kg protein and 600 mg phosphate daily is crucial for preserving kidney function in patients with moderate renal insufficiency.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[A case of acute renal failure secondary to late-onset McArdle's disease].

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2013
Same author

Incidence of primary and second cancers in renal transplant recipients: a multicenter cohort study.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2012
Same author

PTCH1 gene haplotype association with basal cell carcinoma after transplantation.

The British journal of dermatology·2010
Same author

The assessment of human health impact caused by industrial and civil activities in the Pace Valley of Messina.

The Science of the total environment·2009
Same author

[Quality of life of the elderly patient on dialysis].

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2008
Same author

[Low-protein dietary therapy in patients with chronic kidney disease].

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2008

Area of Science:

  • Nephrology
  • Dietary Science
  • Renal Medicine

Background:

  • Chronic renal failure (CRF) management requires careful consideration of dietary factors.
  • Protein and phosphate intake are known modulators of renal function progression.

Purpose of the Study:

  • To evaluate the impact of different dietary protein and phosphate levels on the progression of renal failure.
  • To determine optimal dietary thresholds for managing CRF patients.

Main Methods:

  • A longitudinal study involving 7 CRF patients with varying GFRs (24-66 ml/min).
  • Three dietary periods were implemented: Period A (low protein/phosphate), Period B (normal protein/phosphate), and Period C (low protein/phosphate).
  • Renal function was assessed by monitoring the slope of 1/serum creatinine (1/Scr) and 125I-iothalamate clearance (GFR).

Related Experiment Videos

Main Results:

  • The slope of 1/Scr indicated disease progression in Period B (-0.016 dl/mg/month) compared to Periods A (0.003 dl/mg/month) and C (0.009 dl/mg/month).
  • Glomerular filtration rate (GFR) declined significantly in Period B (from 51.9 to 40.7 ml/min/1.73 m2) but improved or remained stable in Periods A and C.
  • Dietary intake exceeding 0.6 g/kg protein and 600 mg phosphate daily was associated with adverse changes in renal function.

Conclusions:

  • Dietary protein and phosphate intake exceeding 0.6 g/kg and 600 mg/day, respectively, can accelerate renal failure progression.
  • Low-protein (0.6 g/kg) and low-phosphate (600 mg) diets are beneficial for preserving kidney function in CRF patients.
  • These findings underscore the importance of dietary management in CRF patients with moderate renal insufficiency.