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Updated: Mar 15, 2026

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity
Published on: January 31, 2025
Ipilimumab-Induced Neutropenia in Melanoma
Makiko Ban-Hoefen1, Richard Burack1, Lynn Sievert1
1University of Rochester Medical Center, Rochester, NY, USA.
Abstract:
Ipilimumab is a human monoclonal IgG1 antibody against CTLA-4 that has been shown to prolong the overall survival of advanced melanoma. The most common adverse events associated with ipilimumab are immune-related. Severe hematological toxicity is rare. We report a case of severe neutropenia following ipilimumab therapy that fully resolved after the administration of prednisone, cyclosporine, and anti-thymocyte globulin therapies.
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