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Related Experiment Video

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Author Spotlight: Comparative Imaging of Neural Activity in Awake and Freely Moving States

Author Spotlight: Comparative Imaging of Neural Activity in Awake and Freely Moving States

Published on: January 19, 2024

Stable long-term chronic brain mapping at the single-neuron level.

Tian-Ming Fu¹, Guosong Hong¹, Tao Zhou¹

¹Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.

|August 30, 2016

Summary

Researchers developed a flexible mesh electronics platform for stable, long-term brain recording and stimulation in mice. This technology enables tracking neural activity and responses over months, advancing neuroscience and medicine.

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Area of Science:

Neuroscience
Biomedical Engineering
Medical Technology

Background:

Stable in vivo neural mapping and modulation are crucial for neuroscience and medicine.
Current implants face limitations like shear motion and immune responses, hindering long-term studies.

Purpose of the Study:

To develop a chronic in vivo recording and stimulation platform using flexible mesh electronics.
To demonstrate stable, long-term neural recordings and stimulation in mouse brains.

Main Methods:

Developed a flexible mesh electronics platform for chronic in vivo recording and stimulation.
Conducted longitudinal studies in freely behaving mice for up to 8 months.
Recorded multiplexed local field potentials and single-unit activities.

Main Results:

Achieved stable recordings for at least 8 months without probe repositioning.
Demonstrated robust tracking of the same neurons over the recording period.
Evoked stable single-neuron responses to chronic electrical stimulation.

Conclusions:

The flexible mesh electronics platform offers a stable solution for long-term neural recording and modulation.
This technology facilitates longitudinal studies of brain function, aging, and diseases.
Potential applications include mapping and modulating changes related to learning and neurodegenerative conditions.