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Acromegaly diagnosis is delayed by 6-8 years, leading to tumor growth and complications. Simple diagnostic tools and personalized treatment are crucial for better acromegaly management.

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Area of Science:

  • Endocrinology
  • Medical Diagnostics

Background:

  • Acromegaly diagnosis is significantly delayed (6-8 years), impacting patient outcomes.
  • Delayed diagnosis leads to pituitary macroadenoma, irreversible complications (arthropathy, sleep apnea), and increased mortality.

Purpose of the Study:

  • To highlight the clinical impact of diagnostic delay in acromegaly.
  • To emphasize the need for simple tools to aid early acromegaly diagnosis.
  • To discuss the importance of global evaluation for therapeutic decision-making in acromegaly management.

Main Methods:

  • Review of clinical impact of diagnostic delay in acromegaly.
  • Discussion of current and future management strategies.
  • Mention of validation of tools like SAGIT for acromegaly management.

Main Results:

  • Diagnostic delay remains a significant issue in acromegaly, with minimal improvement over 20 years.
  • Majority of patients (2/3) present with pituitary macroadenoma.
  • Irreversible complications and increased mortality are direct consequences of delayed diagnosis.

Conclusions:

  • Simple, sensitive, and specific diagnostic tools are needed to reduce acromegaly diagnostic delay.
  • Global evaluation during follow-up is crucial for personalized treatment decisions.
  • Advancements in treatment options will facilitate personalized acromegaly care, considering patient preferences and complication control.