Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biofilms01:29

Biofilms

1.8K
Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safe obstetric anaesthesia in low- and middle-income countries-a perspective from Africa.

BJA education·2023
Same author

Jupiter's X-Ray and UV Dark Polar Region.

Geophysical research letters·2022
Same author

Prevention and management of intra-operative pain during caesarean section under neuraxial anaesthesia: a technical and interpersonal approach.

Anaesthesia·2022
Same author

The novel Mechanical Ventilator Milano for the COVID-19 pandemic.

Physics of fluids (Woodbury, N.Y. : 1994)·2021
Same author

Reducing long acting antipsychotic injection dosage frequency: A pilot study in a community mental health team.

Journal of mental health (Abingdon, England)·2020
Same author

14 hours to see the consultant…tick…tock.

Future healthcare journal·2019

Related Experiment Video

Updated: Mar 15, 2026

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
09:39

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries

Published on: December 27, 2016

18.7K

Host Responses to Biofilm.

C Watters1, D Fleming2, D Bishop1

  • 1Wound Infections Department, Naval Medical Research Center, Silver Spring, MD, United States.

Progress in Molecular Biology and Translational Science
|August 31, 2016
PubMed
Summary
This summary is machine-generated.

Bacterial biofilms, communities of microbes, can evade immune detection by hiding within an extracellular matrix. Probiotic biofilms, however, show anti-inflammatory properties and protect host tissues.

Keywords:
EPS matrixLactobacillus biofilmsM2 macrophagesPseudomonas aeruginosaStaphylococcus aureusbacterial immune responsebiofilmsextracellular DNAneutrophil lysisprobiotics

More Related Videos

Generation of Greater Bacterial Biofilm Biomass using PCR-Plate Deep Well Microplate Devices
10:57

Generation of Greater Bacterial Biofilm Biomass using PCR-Plate Deep Well Microplate Devices

Published on: April 22, 2022

9.3K
Microtiter Dish Biofilm Formation Assay
03:57

Microtiter Dish Biofilm Formation Assay

Published on: January 30, 2011

116.0K

Related Experiment Videos

Last Updated: Mar 15, 2026

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
09:39

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries

Published on: December 27, 2016

18.7K
Generation of Greater Bacterial Biofilm Biomass using PCR-Plate Deep Well Microplate Devices
10:57

Generation of Greater Bacterial Biofilm Biomass using PCR-Plate Deep Well Microplate Devices

Published on: April 22, 2022

9.3K
Microtiter Dish Biofilm Formation Assay
03:57

Microtiter Dish Biofilm Formation Assay

Published on: January 30, 2011

116.0K

Area of Science:

  • Microbiology
  • Immunology
  • Biochemistry

Background:

  • The human immune system constantly interacts with bacteria.
  • Biofilms, microbial communities in an extracellular polymeric substance (EPS) matrix, are involved in both health and disease.
  • Bacterial components can be masked within biofilms, altering immune recognition.

Purpose of the Study:

  • To explore how bacterial biofilms interact with the host immune system.
  • To understand the role of the EPS matrix in immune evasion.
  • To investigate the differential immune responses to pathogenic versus probiotic biofilms.

Main Methods:

  • Analysis of immune cell interactions with biofilm components.
  • Investigation of molecular signaling during biofilm formation.
  • Comparison of immune responses to planktonic bacteria versus biofilm communities.

Main Results:

  • Biofilm growth can camouflage bacterial antigens, hindering immune cell recognition.
  • The EPS matrix, composed of DNA, proteins, polysaccharides, and lipids, is a key interface with the immune system.
  • Pathogenic biofilms can enhance their formation and resist immune cells like neutrophils and macrophages.
  • Probiotic Lactobacillus biofilms elicit minimal immune response and possess anti-inflammatory properties.

Conclusions:

  • Bacterial biofilms present unique challenges to host immunity.
  • The EPS matrix plays a critical role in biofilm survival and immune modulation.
  • Probiotic biofilms offer potential therapeutic benefits due to their anti-inflammatory effects and protective colonization.