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Related Experiment Video

Updated: Mar 15, 2026

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
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Insights From Genomics Into Spatial and Temporal Variation in Batrachochytrium dendrobatidis.

A Q Byrne1, J Voyles2, G Rios-Sotelo2

  • 1Department of Environmental Science Policy and Management, University of California, Berkeley, CA, United States.

Progress in Molecular Biology and Translational Science
|August 31, 2016
PubMed
Summary

Genomic tools reveal unexpected complexity in the fungal pathogen Batrachochytrium dendrobatidis (Bd), a deadly amphibian disease agent. This highlights that emerging pathogen biology is more intricate than initially presumed.

Keywords:
Batrachochytrium dendrobatidisChytridiomycosisamphibian declinesgeneticsgenomics

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Area of Science:

  • * Infectious disease research
  • * Genomics and bioinformatics
  • * Amphibian pathology

Background:

  • * Emerging infectious diseases pose significant threats to global health and biodiversity.
  • * Genetics and genomics offer powerful tools for rapid pathogen analysis.
  • * Batrachochytrium dendrobatidis (Bd) is a novel, deadly fungal pathogen impacting amphibian populations worldwide.

Purpose of the Study:

  • * To apply genomic approaches to understand the biology of Batrachochytrium dendrobatidis (Bd).
  • * To explore the genetic variation and complexity within the Bd pathogen system.
  • * To identify new research avenues for studying emerging fungal pathogens.

Main Methods:

  • * Utilized advanced genetics and genomics techniques.
  • * Analyzed genomic data to infer pathogen origin, spread, and virulence.
  • * Reviewed existing literature and research findings on Bd.

Main Results:

  • * Genomic analyses uncovered significant and unexpected genetic variation within Bd.
  • * Insights into the pathogen's evolutionary history and population structure were gained.
  • * The complexity of Bd's biology and its impact on amphibians was elucidated.

Conclusions:

  • * Genomic tools provide crucial insights into the intricate biology of emerging pathogens like Bd.
  • * The study of emerging infectious diseases requires acknowledging and investigating their inherent complexity.
  • * Future research should leverage genomic approaches to further unravel pathogen diversity and host-pathogen interactions.