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Related Concept Videos

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
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Related Experiment Video

Updated: Mar 15, 2026

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
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Platelet corrected count increments by apheresis platform.

Aaron A R Tobian1, Karen E King2, Prabhakar D Borge3

  • 1Department of Pathology, Johns Hopkins University, Baltimore, Maryland. atobian1@jhmi.edu.

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|August 31, 2016
PubMed
Summary
This summary is machine-generated.

Platelets collected using the Trima Accel system showed higher corrected count increment (CCI) in oncology patients compared to the Amicus system, suggesting better in vivo viability. This highlights the importance of optimizing apheresis platelet collection methods.

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Area of Science:

  • Transfusion Medicine
  • Hematology
  • Biomedical Engineering

Background:

  • Automated blood collection platforms utilize diverse technologies for blood component isolation.
  • Different collection systems may impact platelet in vivo viability, assessed by corrected count increment (CCI).

Purpose of the Study:

  • To compare the in vivo viability of apheresis platelets collected using two distinct automated systems in oncology patients.

Main Methods:

  • A retrospective analysis of corrected count increment (CCI) data from oncology patients receiving apheresis platelets.
  • Platelets were collected between 2006-2009 using two systems: Trima Accel and Amicus, and transfused in a blinded manner.

Main Results:

  • Platelet transfusions collected via the Trima Accel system demonstrated a significantly higher CCI (mean=6281) at 0-2 hours post-transfusion compared to the Amicus system (mean=5251).
  • The difference in CCI between the two collection systems was statistically significant (p=0.004).

Conclusions:

  • Data suggest improved recovery and survival of platelets collected with the Trima Accel system.
  • Further investigation into optimal apheresis collection methods is warranted to enhance platelet transfusion support.