Adipokine Pattern After Bariatric Surgery: Beyond the Weight Loss
Related Experiment Video
Updated: Mar 15, 2026

Roux-en-Y Gastric Bypass Operation in Rats
Published on: June 11, 2012
Gian Franco Adami1,2, Nicola Scopinaro3,4, Renzo Cordera3
1Department of Internal Medicine, University of Genova, Genova, Italy. adami@unige.it.
Abstract:
Besides the role in energy storing and body health isolating, adipose tissue produces proteins, the so-called adipokines, with pro-inflammatory or anti-inflammatory actions that contribute to metabolic control and to appetite and energy expenditure regulation. The marked adipose tissue loss following bariatric surgery corresponds to a rearrangement of serum adipokine pattern, with increase of anti-inflammatory and decrease of pro-inflammatory agents. This might play a relevant role in the postoperative improvement of metabolic conditions. However, after surgically induced weight loss, other investigations failed to evidence significant modifications of serum concentration of some adipokines. This review speculates that the composition of adipose tissue lost could influence postoperative changes in some adipokine concentration and that an adequate adipokine pattern plays a pivotal role for the long-term metabolic outcome.
Related Concept Videos
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
Metabolic States of the Body: The Postabsorptive State
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
Metabolic States of the Body: The Absorptive State
Obesity
Metabolic States of the Body: Fasting and Starvation

