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Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples
Published on: July 6, 2014
HIV Infection and Survival Among Women With Cervical Cancer
Scott Dryden-Peterson1, Memory Bvochora-Nsingo1, Gita Suneja1
1Scott Dryden-Peterson, Akila N. Viswanathan, and Shahin Lockman, Brigham and Women's Hospital; Scott Dryden-Peterson and Shahin Lockman, Harvard T.H. Chan School of Public Health; Scott Dryden-Peterson, Jason A. Efstathiou, Akila N. Viswanathan, Anthony H. Russell, Thomas C. Randall, Bruce Chabner, and Shahin Lockman, Harvard Medical School; Jason A. Efstathiou, Rebecca Clayman, Anthony H. Russell, Thomas C. Randall, and Bruce Chabner, Massachusetts General Hospital; Akila N. Viswanathan, Dana-Farber Cancer Institute, Boston, MA; Scott Dryden-Peterson, Abigail C. Mapes, Neo Tapela, Aida Asmelash, Mompati Mmalane, and Shahin Lockman, Botswana Harvard AIDS Institute Partnership; Memory Bvochora-Nsingo, Gaborone Private Hospital; Sebathu Chiyapo, Princess Marina Hospital; Doreen Ramogola-Masire, Botswana-University of Pennsylvania Partnership; Malebogo Kebabonye-Pusoentsi, Neo Tapela, Heluf Medhin, and Mukendi K.A. Kayembe, Botswana Ministry of Health, Gaborone, Botswana; Gita Suneja, University of Utah School of Medicine, Salt Lake City, UT; and Surbhi Grover and Lilie L. Lin, University of Pennsylvania, Philadelphia, PA.
Human immunodeficiency virus (HIV) significantly reduces survival rates for women diagnosed with invasive cervical cancer, even with access to antiretroviral therapy. This highlights the critical impact of HIV on cancer outcomes.
Area of Science:
- Oncology
- Infectious Diseases
- Epidemiology
Background:
- Cervical cancer is a leading cause of cancer death for women with HIV globally.
- Understanding the impact of HIV on cervical cancer survival is crucial for effective patient management.
Purpose of the Study:
- To determine if human immunodeficiency virus (HIV) infection affects survival rates in women diagnosed with invasive cervical cancer.
- To analyze the relationship between HIV status and cervical cancer mortality in a specific patient cohort.
Main Methods:
- A cohort of 348 women with cervical cancer in Botswana (2010-2015) was studied.
- Standard treatment involved radiation, brachytherapy, and cisplatin chemotherapy.
- An inverse probability weighted marginal Cox model was used to estimate the effect of HIV on survival.
Main Results:
- Women with HIV (n=231) had significantly lower 3-year survival (35%) compared to those without HIV (n=96, 48%).
- HIV infection was associated with a nearly twofold increased risk of death (HR, 1.95).
- The adverse effect of HIV was more pronounced in women with earlier stage cancer and lower CD4 counts.
Conclusions:
- Despite access to antiretroviral therapy, HIV significantly decreases cervical cancer survival.
- Advanced cancer stage and incomplete treatment contribute to high mortality.
- HIV remains a critical factor influencing outcomes for women with cervical cancer.
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