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Chest pain after percutaneous coronary intervention in patients with stable angina
Chao-Chien Chang1, Yueh-Chung Chen2, Eng-Thiam Ong3
1Division of Cardiology, Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan, ROC; Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan, ROC; Department of Pharmacology, Taipei Medical University, Taipei, Taiwan, ROC.
Insights
Post-procedural chest pain (PPCP) is common after percutaneous coronary intervention (PCI) in stable angina patients. Abnormal ECG changes, troponin I elevation, and stent number predict PPCP.
Area of Science:
- Cardiology
- Interventional Cardiology
- Clinical Medicine
Background:
- Percutaneous coronary intervention (PCI) is widely used for acute coronary syndrome.
- PCI is an additional treatment for refractory angina.
- Post-PCI chest pain (PPCP) is a common issue, but its causes in stable angina are unclear.
Purpose of the Study:
- To determine the incidence and predictors of post-PCI chest pain (PPCP) in patients with stable angina.
- To understand the clinical implications of PPCP in this patient group.
Main Methods:
- Retrospective collection of clinical data from 167 stable angina patients undergoing elective PCI.
- Comparison of 70 patients with PPCP to 97 patients without PPCP within 24 hours post-procedure.
- Analysis of incidence and predictors of PPCP.
Main Results:
- The incidence of PPCP was 41.9%.
- PPCP patients showed more abnormal post-PCI ECG changes, elevated cardiac troponin I (cTnI), more PCI vessels, and stent placements.
- PPCP was strongly correlated with abnormal post-PCI ECG, cTnI elevation, and number of stents placed.
Conclusions:
- Post-PCI chest pain (PPCP) is a frequent occurrence in stable angina patients.
- Abnormal ECG changes, cTnI elevation, and the number of stents placed are significant predictors of PPCP.
- PPCP patients required more repeat revascularization.
Background:
Percutaneous coronary intervention (PCI) has been widely used to treat acute coronary syndrome but is only recommended as an additional treatment to medical therapy and risk modification in patients with refractory or progressing angina. The number of PCI in this patient population is still increasing. Post-PCI chest pain (PPCP) is one of the common problems of PCI. Its presentation and causes in patients with stable angina are poorly understood.
Patients And Methods:
This study retrospectively collected clinical information of 167 patients who had stable angina and underwent elective PCI, including 70 patients with PPCP 24 hours after procedure and 97 patients without PPCP. The incidence and predictors of PPCP were analyzed.
Results:
The incidence of PPCP was 41.9% (70/167). Compared with non-PPCP patients, PPCP patients had more abnormal post-PCI electrocardiogram (ECG) changes (new Q-waves, ST-segment shifts, or T-waves inversion) and serum cardiac troponin I (cTnI) elevation, more PCI vessels, and stent placement (all P<0.05). More PPCP patients required repeat revascularization than non-PPCP patients after PCI (P=0.043). PPCP was correlated with abnormal post-PCI ECG changes (P<0.0001), cTnI elevation (P<0.0001), post-PCI serum level of cTnI (P<0.0001), number of stents placed (P=0.009), and pre-PCI cTnI level (P=0.049). The strongest predictors of PPCP were abnormal post-PCI ECG changes (P<0.0001), post-PCI cTnI level (P<0.0001), and cTnI elevation (P<0.0001), followed by the number of stents placed (P=0.048).
Conclusion:
PPCP is common in patients with stable angina in our cohort. It is associated with abnormal ECG changes, cTnI elevation, and number of stents placed.
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