Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

3.4K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.4K
Burn Injuries01:22

Burn Injuries

4.9K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
4.9K
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

5.7K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
5.7K
Phases of Wound Repair01:28

Phases of Wound Repair

9.3K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
9.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Uncovering the treasure chest of burn care and research data.

Burns : journal of the International Society for Burn Injuries·2024
Same author

Development of a value-based healthcare burns core set for adult burn care.

Burns : journal of the International Society for Burn Injuries·2024
Same author

Biopsychosocial complexity in patients scheduled for elective TKA surgery: A feasibility pilot study with the INTERMED self-assessment questionnaire.

International journal of orthopaedic and trauma nursing·2024
Same author

The Prevention of Musculoskeletal Complaints in Instrumental Musicians: A Systematic Review.

Medical problems of performing artists·2023
Same author

A dual marker technique to estimate individual feed intake in young pigs.

Animal : an international journal of animal bioscience·2022
Same author

Within-patient randomized clinical trial comparing incisional negative-pressure wound therapy with suction drains in gender-affirming mastectomies.

The British journal of surgery·2021

Related Experiment Video

Updated: Mar 15, 2026

Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes
02:49

Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes

Published on: February 23, 2024

2.2K

Tissue engineering in burn scar reconstruction.

Ppm van Zuijlen1, Klm Gardien2, Meh Jaspers1

  • 1Burn Center, Red Cross Hospital, Beverwijk, The Netherlands ; Department of Plastic, Reconstructive and Hand Surgery, Red Cross Hospital, Beverwijk, The Netherlands ; Association of Dutch Burn Centers, Beverwijk, The Netherlands ; Department of Plastic, Reconstructive and Hand Surgery, MOVE Research Institute, VU University Medical Center, Amsterdam, The Netherlands.

Burns & Trauma
|August 31, 2016
PubMed
Summary
This summary is machine-generated.

Severe burn survivors face challenges with large wounds. Tissue engineering offers solutions for permanent burn wound coverage and reconstructive surgery, including skin, fat, and cartilage replacement.

Keywords:
BurnsCartilageContractureReconstructionScarSubcutaneous fat tissueSubstituteTissue engineering

More Related Videos

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft
12:18

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft

Published on: August 8, 2020

11.1K
Engineered Vascularized Muscle Flap
08:18

Engineered Vascularized Muscle Flap

Published on: January 11, 2016

8.8K

Related Experiment Videos

Last Updated: Mar 15, 2026

Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes
02:49

Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes

Published on: February 23, 2024

2.2K
A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft
12:18

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft

Published on: August 8, 2020

11.1K
Engineered Vascularized Muscle Flap
08:18

Engineered Vascularized Muscle Flap

Published on: January 11, 2016

8.8K

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Plastic and Reconstructive Surgery

Background:

  • Advances in severe burn care increase survival rates, leading to more patients with extensive burn scars.
  • Large-volume burn injuries present significant reconstructive challenges, necessitating innovative treatment strategies.

Purpose of the Study:

  • To provide a comprehensive overview of tissue engineering advancements for permanent burn wound coverage.
  • To evaluate the clinical effectiveness and applications of novel tissue-engineered substitutes in reconstructive burn surgery.

Main Methods:

  • Review of current literature on tissue engineering for burn wound management.
  • Analysis of studies focusing on skin substitutes, subcutaneous fat tissue, and cartilage replacement.

Main Results:

  • Tissue engineering offers promising solutions for complex burn reconstructions.
  • Clinical effectiveness varies among different tissue-engineered products and applications.

Conclusions:

  • Tissue engineering is crucial for addressing the sequelae of severe burns, improving patient outcomes.
  • Further research is needed to optimize the use of tissue-engineered constructs for long-term reconstructive success.