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Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

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Endoscopic peroral jejunal fecal microbiota transplantation

Alexander Link1, Tim Lachmund1, Christian Schulz1

  • 1Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University, Magdeburg, Germany.

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
|August 31, 2016
PubMed
Abstract

Insights

High-volume fecal microbiota transplantation (FMT) via endoscopic jejunal route effectively cures recurrent Clostridium difficile colitis. While generally safe, potential aspiration risk requires careful consideration during the procedure.

Area of Science:

  • Gastroenterology
  • Microbiome Research
  • Infectious Diseases

Background:

  • Fecal microbiota transplantation (FMT) is a key treatment for recurrent Clostridium difficile (C. difficile) colitis.
  • Optimal FMT delivery route and volume require further investigation.
  • This study explores high-volume FMT using an endoscopic jejunal application route.

Purpose of the Study:

  • To evaluate the efficacy and safety of high-volume FMT via endoscopic jejunal administration.
  • To assess patient tolerance and potential complications associated with this method.

Main Methods:

  • A prospective observational study involving FMT from healthy donors to patients with C. difficile colitis.
  • Specimens (≥50g in 500ml electrolyte solution) were administered endoscopically into the jejunum.
  • Route selection was based on patient preference.

Main Results:

  • All FMT procedures resulted in the cure of C. difficile colitis.
  • The procedure was well-tolerated in most cases.
  • Complications included jejunal reflux into the stomach and one case of tracheal aspiration leading to pneumonia.

Conclusions:

  • High-volume endoscopic jejunal FMT is an effective and well-tolerated treatment for C. difficile colitis.
  • The procedure is technically straightforward to perform.
  • Aspiration is a significant risk that necessitates vigilance during FMT administration.
Keywords:
ApplicationAspirationEndoscopyFecal microbiota transplantation

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